Following the great success of ICCAIS 2018 & 2019, we introduced ICCAIS 2020. 2020 Version was unique, it was a virtual conference conducted completely through video conference with great success. This version of ICCAIS concentrates more at higher level of research work. 2021 offers a more streamlined networking track, as well as a comprehensive track in computer applications. Sampling tracks on advanced topics and mechatronics are similarly added for the second year. We hope this will give the authors better tracks coverage. Version 2018 saw an introduction of ICCAIS as an international and strong name in IEEE technically co-sponsored events. Version 2019 saw the enforcement of video conferencing as a good method of presentation that enables volatility as well as equal opportunities to aspiring authors world-wide. It, additionally, saw the introduction of the Best Paper Award. A tradition, we aim, at maintaining.